Identification of the 2- -1 subunit of voltage- dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin
نویسندگان
چکیده
*Department of Pain Therapeutics and Animal Welfare Group, Discovery Biology, Pfizer Global Research and Development, Sandwich Laboratories, B500 IPC 351, Sandwich, Kent CT13 9NJ, United Kingdom; §Department of Molecular Sciences, Pfizer Global Research and Development, Ann Arbor, MI 48105; and ¶Laboratory of Cellular and Molecular Neuroscience, Department of Pharmacology, University College London, Andrew Huxley Building, Gower Street, London WC1E 6BT, United Kingdom
منابع مشابه
Gabapentinoids: Gabapentin and Pregabalin for Postoperative Pain Management
Postsurgical pain is normally perceived as nociceptive pain. Surgical trauma has been known to induce central and peripheral sensitization and hyperalgesia, which in untreated cases could lead to chronic postoperative pain after surgery. Indeed pain is one of the three most common medical causes of delayed discharge after ambulatory surgery, the other two being drowsiness and nausea/ vomiting. ...
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Background: Pregabalin, a selective inhibitor of voltage dependent calcium channels has been used for treatment of epilepsy, fibromyalgia, generalized anxiety disorder and especially neuropathic pains. The anti-inflammatory properties of pregabalin in some pathologic conditions like orofacial pain and streptozotocin-induced diabetic mice have been reported. Effectiveness of pregabalin in treatm...
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